Collagen matrix designed for difficult cases
The BioBridge® Collagen Matrix is a new sterile implantable surgical mesh designed to provide support for the surgical treatment of lymphedema. This innovative threaded product is made from porcine collagen subjected to a rigorous purification process using Fibralign’s patented Nanoweave® technology, giving it the biological properties needed to rebuild and restore lymphatic paths’ function.
The implantation of the BioBridge biological implant is a minimally invasive procedure. The implant biodegrades and integrates into anatomical structures in the long term. Although the BioBridge implant is a new, ground-breaking support method for the treatment of lymphedema, it has already been used in several hundred cases requiring surgical treatment, where it has been proven to be a safe and effective treatment for lymphedema occurring in the upper and lower limbs. It is routinely part of hybrid reconstruction and support for standard reconstructive techniques: lymphatic-venous anastomosis (LVA) and lymph node transfer (LNT).
The clinical cases analysed showed a significant reduction in limb volume and its return to normal size in a significant proportion of operated patients.
Lower Limb Lymphedema Before and After Surgery with LNT and BioBridge Preop Vdiffer = 35% – Postop Vdiffer = 7%
Upper Limb Lymphedema Before and After Surgery with LNT and BioBridge
Preop Vdiffer = 21% – Postop Vdiffer = 9%
Proven Performance and Safety
- Bioengineered native tissue structure produced from only highly purified Type 1 porcine atelocollagen (pepsin treated)
- Biocompatible, minimizes patient immunogenic response
- Design to integrate into tissue and safely fully resorb
- Highly porous multilumenal structure, promotes capillary flow
- Ready to use, provided in single-use sterile packaging
- High effectiveness in lymphatic system reconstruction procedures
BioBridge up close (1500x magnification): Fibralign’s Nanoweave technology enables the formation of a scaffold with native tissue nanostructure from highly purified atelocollagen — providing the mechanical properties needed for lymphatic repair while minimizing the immunogenic response.
Cross-section (190x magnified): BioBridge’s thin ribbon structure provides a highly porous matrix with very high surface area, making it ideal for cell attachment and excellent tissue integration.